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Onyx and Multiple Myeloma Research Foundation announce multi-year collaboration to accelerate personalized medicine approaches for multiple myeloma.

Results from a Phase 3 study evaluating regorafenib, a Bayer owned compound, demonstrate an improvement in overall survival in patients with metastatic colorectal cancer.  Bayer plans to file for approval in the United States and Europe in 2012.

Onyx expands its global oncology partnership with Bayer and enters into a new agreement for regorafenib.  Under the terms of the agreement, Onyx will receive a 20% royalty on global net sales of regorafenib if the therapy is approved.

FDA accepts the carfilzomib New Drug Application for review under the accelerated approval pathway for potential treatment of patients with relapsed and refractory multiple myeloma.

Onyx and Multiple Myeloma Research Foundation launch Carfilzomib Myeloma Access Program (C-MAP), an expanded access program that makes carfilzomib available to eligible patients in the United States with relapsed and refractory multiple myeloma.

U.S. FDA grants carfilzomib Fast Track Designation for the potential treatment of patients with relapsed and refractory multiple myeloma; Onyx initiates rolling New Drug Application submission for accelerated approval.

Onyx reports positive complete results from Phase 2b study of single-agent carfilzomib in patients with relapsed and refractory multiple myeloma.

Onyx enters into an exclusive agreement valued in excess of $300 million with Ono Pharmaceutical, giving Ono the rights to develop and commercialize carfilzomib and ONX 0912 for all oncology indications in Japan.

Phase 3 ASPIRE trial begins, evaluating carfilzomib in combination with lenalidomide (Revlimid) and low-dose dexamethasone in patients with relapsed multiple myeloma.

ONX 0912, an oral proteasome inhibitor, enters clinical testing.

Onyx acquires Proteolix Inc., a privately held biopharmaceutical company focused on discovering and developing novel therapies that target the proteasome for the treatment of patients with cancer and autoimmune diseases.

Phase 3 DECISION trial begins, evaluating Nexavar in patients with radioactive iodine-refractory, locally advanced or metastatic differentiated thyroid cancer.

Onyx and Bayer report positive results from a Phase 2 trial evaluating Nexavar plus the chemotherapeutic agent, capecitabine, in patients with advanced breast cancer.

Phase 3 MISSION trial begins, evaluating Nexavar in patients with NSCLC who have failed two or three previous treatments.

Phase 2 SPACE trial begins, evaluating Nexavar in combination with TACE.

Phase 3 SEARCH trial begins, evaluating Nexavar in combination with Tarceva.

Hollings Renton retires as chairman and CEO of Onyx.

N. Anthony Coles, M.D., joins Onyx as president and CEO.

Nexavar pivotal liver cancer study (SHARP) published in The New England Journal of Medicine.

Onyx acquires license to ONX 0801, a novel targeted oncology compound in preclinical development.

Nexavar pivotal kidney cancer study (TARGET) published in The New England Journal of Medicine.

Nexavar is approved as the first and only systemic therapy for the treatment of patients with unresectable liver cancer.

Nexavar is approved for the treatment of patients with advanced kidney cancer; the first new medicine in more than a decade to treat this disease.

PD 0332991, an oral, cell cycle inhibitor, enters clinical testing.

Onyx focuses its efforts solely on the development of sorafenib and discontinues therapeutic virus program.

Sorafenib (now Nexavar), an oral systemic therapy, enters clinical testing.

Onyx and Warner Lambert, now Pfizer, extend collaboration in area of cell cycle regulation.

Frank McCormick leaves Onyx to become head of the University of California, San Francisco Cancer Center and Cancer Research Institute.

Onyx completes IPO and is listed on the Nasdaq under stock symbol ONXX.

Onyx and Warner Lambert, now Pfizer, form collaboration to develop therapeutics for cell cycle regulation.

Onyx and Miles Inc. (predecessor to Bayer HealthCare Pharmaceuticals, Inc.) form collaboration.

Onyx appoints Hollings Renton as the company’s first president and CEO.

Onyx Pharmaceuticals is founded by Frank McCormick to discover and develop cancer therapeutics and is spun out of the Cetus and Chiron merger as privately held company.

Cetus Corporation merges with Chiron Corporation.

Frank McCormick, Ph.D., begins cancer research program at Cetus Corporation.